12/29/2023 0 Comments Schizophrenia auditory hallucination![]() ![]() In the future, it will be important to investigate the meditation‐evoked brain changes to further elucidate the potential mechanisms of the benefits from intervention. Second, mindfulness training increases acceptance and ameliorates anxiety/distress emotion, resulting in general improvement in psychotic symptoms. First, mindfulness meditation produces brain oscillation changes and increases brain network integration, 7 which could contribute to the decreased abnormal brain activities and reduced hallucination/delusion. There are several potential mechanisms underlying the interventional effects of mindfulness meditation on hallucination and delusion. In present study, we reported the effectiveness of 8‐month mindfulness meditation intervention in five severe schizophrenia patients with more than 20 years’ medical history. In addition, the quality of life index in SF‐36 and mindfulness score in FFMQ improved significantly following intervention ( P < 0.05 Table Table3 3). Notably, the PANSS positive symptoms and negative symptoms both decreased following intervention ( P < 0.05 Table Table2). At the end of 8‐month intervention period, significant reductions in both hallucination and delusion symptoms were observed in all patients ( P < 0.05 Figure Figure1). The improvements persisted as the intervention continued. Following mindfulness training intervention, the hallucination and delusion symptoms did not exhibit much change in the first 2 weeks but began to decrease after 3 weeks of intervention. The hallucination and delusion symptoms persisted and exhibited no change during the past 8 years (measured at 8 years ago, 4 years ago, 2 weeks ago, and baseline time point) prior to this study. The data were analyzed with SPSS 18.0 software (SPSS Inc., Chicago, IL, USA) paired‐sample t test was used for differences before and after intervention. The records were double checked and confirmed by the tutors. During the continuous 8 months period, the patients performed mindfulness meditation per day for 20‐40 minutes. In the first 8 weeks, the group intervention (90 minutes each, led by two experienced tutors) was conducted per week, and after the period, the group intervention frequency was once per month. Mindfulness meditation was performed with following procedures. Intervention: 8 months, group intervention, and individual training.įollow‐up: 1, 2, 3, 4, 5, 6, 7, 8 weeks and 8 months after start point of intervention for the hallucination and delusion symptoms, and relevant scales. Registered Decem(retrospectively registered).įebruary 2017: Recruitment of patients and start of the trial. The registration number is ChiCTR‐OOB‐17014038. This clinical trial has been registered on the Chinese Clinical Trial Registry ( ). Informed consent was as well obtained for the publication of this case report. The study has been approved by the ethic committee of medical research in the Minzheng hospital, and written informed consents were obtained from all patients for the study, or the guardians/next of kin of these participants when in need. The Positive and Negative Syndrome Scale (PANSS), Short Form‐36 Health Survey (SF‐36), and Five Facet Mindfulness Questionnaire (FFMQ) were measured by an expert clinical psychologist. These patients demonstrated severe and drug treatment‐resistant hallucination/delusions (score >5 Details in Table Table1). All patients received active antipsychotics treatment upon admission (at higher doses than patients on average): chlorpromazine equality averaged at 670.00 ± 176.47 mg/d (ranged 487.5‐900). 6 It is unknown if mindfulness meditation could reduce positive symptoms in the chronic schizophrenia patients.įive male patients, averaged age at 55.80 ± 9.45 years old (ranged 44‐66 years), with averaged medical history of 30.20 ± 8.53 years (ranged 21‐41 years) were recruited for present study. 1, 2, 3 In schizophrenic patients, mindfulness intervention leads to better psychosocial functioning, 4 improved positive emotions, 5 and reduced negative symptoms. Mindfulness meditation alleviates symptoms of distress, pain, and many chronic diseases.
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